Product Description

Known For: South Carolina’s only academic medical center offering ketamine therapy — housed within the nationally ranked MUSC Health system. Provides ketamine within a psychotherapy framework, combining the medicine with therapeutic support in a way few private clinics match.

HealingMaps Take: MUSC Centerspace Clinic brings the weight of an academic medical center to ketamine therapy in the Lowcountry. The Medical University of South Carolina is nationally ranked in psychiatry research and has been at the forefront of ketamine studies for years. Centerspace is the clinical translation of that research — a dedicated clinic where ketamine (intranasal spray and IM injection) and Spravato are administered within a psychotherapy framework by academic psychiatrists and psychotherapists. This is not a drive-through infusion model; it is a therapy-integrated approach where the ketamine and the psychotherapy work together. The institutional backing means MUSC protocols are evidence-based at a level that private clinics cannot match — these are the researchers who generate the evidence. Insurance acceptance through MUSC Health billing is broader than any private ketamine clinic in the region. The trade-off is the academic medical center experience: scheduling can take longer, the environment is clinical, and the bureaucracy of a large health system is real. But for patients with complex presentations, those who want the highest level of clinical oversight, or those whose insurance will not cover private ketamine clinics, MUSC Centerspace is the gold standard in South Carolina.

Patient Review

“Being treated at MUSC gave me confidence that my ketamine protocol was based on actual research, not marketing. The therapy integration during and after sessions made it far more effective than the standalone infusions I tried at a private clinic. My insurance covered most of the cost.”

About MUSC Centerspace Clinic

MUSC Centerspace Clinic is the ketamine therapy program of the Medical University of South Carolina Health system, located at 1470 Tobias Gadson Blvd, Suite 107, Charleston, SC 29407. The clinic offers ketamine intranasal spray, intramuscular ketamine injection, and FDA-approved Spravato (esketamine) within a psychotherapy framework. Operated by MUSC Health’s Department of Psychiatry, Centerspace provides evidence-based ketamine treatment for treatment-resistant depression, major depressive disorder, PTSD, and suicidal ideation. MUSC Health accepts most major insurance plans.

For more on how ketamine therapy works, see our complete guide to ketamine therapy.

What People Like

Academic medical center — highest level of evidence-based care in South Carolina. Ketamine delivered within psychotherapy framework — not standalone infusion. Nationally ranked MUSC Health psychiatry program. Broad insurance acceptance through hospital billing. Multiple ketamine routes (intranasal, IM, Spravato). Research-backed protocols from institution that generates ketamine research.

What People Don’t Like

Academic medical center environment — clinical rather than comfortable. Longer wait times for appointments than private clinics. No IV ketamine listed. Scheduling and billing can involve hospital bureaucracy. Hours limited to weekday business hours (Mon-Thu 8-5, Fri 8-4). May feel impersonal compared to boutique clinics.

Getting Started at MUSC Centerspace Clinic

Call (843) 876-1193 to schedule an appointment at MUSC Centerspace Clinic. Located at 1470 Tobias Gadson Blvd, Suite 107, Charleston, SC 29407. Open Monday-Thursday 8am-5pm, Friday 8am-4pm.

Learn more about the evidence behind ketamine for depression at the National Institute of Mental Health.