Product Description
Known For: Research-backed psychedelic-assisted therapy led by one of the field’s most experienced ketamine psychiatrists, Dr. Casey Paleos.
| Review Scores | Featured in DoubleBlind Magazine |
| Location | New York City, NY |
| Address | 137 E 25th St, 11th Floor, New York, NY 10010 |
| Phone | (917) 336-2608 |
| Website | innermost.one |
| Treatments | IV Ketamine (KIWI, KIT, KAP formats), Spravato (Esketamine), Psychotherapy (IFS, AEDP, Gestalt), Harm Reduction & Integration |
| Conditions Treated | Depression, Anxiety, PTSD & Trauma, Suicidal Ideation, Substance Use Disorder, Chronic Illness-Related Mental Health |
| Cost | Initial session $300; standard visit $600 |
| Insurance | Accepts most major insurance plans |
| KAP Available? | Yes |
| Clinical Lead | Dr. Casey Paleos, M.D. — Board-Certified Psychiatrist, 12+ years psychedelic medicine research & clinical practice |
HealingMaps Take: InnerMost represents the cutting edge of ketamine therapy in Manhattan. Co-founded by Dr. Casey Paleos — a board-certified psychiatrist with over 12 years of clinical and research experience in psychedelic medicine — the clinic combines ketamine treatment with trauma-informed psychotherapy modalities like IFS, AEDP, and Gestalt. InnerMost also runs clinical research trials and trains therapists, making it one of the most academically rigorous ketamine programs in NYC.
Patient Review
“InnerMost’s approach goes beyond just administering medication — the integration of psychotherapy with ketamine treatment made a real difference in my recovery.”
About InnerMost
InnerMost is a psychedelic therapy center in Manhattan’s NoMad neighborhood, co-founded by Dr. Casey Paleos (Chief Medical Officer) and Valentin Somma, PhD (CEO). The clinic offers multiple ketamine therapy formats — KIWI (ketamine infusion with integration), KIT (ketamine integration therapy), and traditional KAP — alongside FDA-approved Spravato. The clinical team includes psychiatrists, psychiatric nurse practitioners, and licensed therapists specializing in trauma-informed care. InnerMost also conducts clinical research trials and provides therapist training programs.
For more on how ketamine therapy works, see our complete guide to ketamine therapy.
What People Like
Patients value the deeply integrated approach combining ketamine with evidence-based psychotherapy. Dr. Paleos’s research background brings a level of clinical rigor that few NYC clinics can match. The team offers harm reduction and psychedelic integration services — signaling a progressive, patient-centered philosophy. Insurance acceptance broadens accessibility.
What People Don’t Like
As a newer clinic (launched late 2025), there’s limited public patient review data compared to more established NYC competitors. The NoMad location, while central, may be less convenient for Brooklyn or Queens residents. Standard visit pricing at $600 may be steep for patients without insurance coverage.
Getting Started at InnerMost
Call (917) 336-2608 or email hello@innermost.one to schedule a consultation. Initial medical consultations are available via telehealth, while all medication sessions are in person. The clinic is open Mon/Wed/Fri 10 AM–6 PM and Tue/Thu 10 AM–8 PM.
Learn more about the evidence behind ketamine for depression at the National Institute of Mental Health.
Reviews
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