Product Description
Known For: The only academic medical center offering ketamine-based treatment in the Cincinnati region — one of 22 National Network of Depression Centers sites in the US. Provides access to 25+ clinical trials and offers both intranasal ketamine AND Spravato protocols.
| Review Scores | Academic institution reputation; patients value access to cutting-edge research and clinical trials |
| Location | Cincinnati, OH |
| Address | 260 Stetson St, Suite 3200, Cincinnati, OH 45219 |
| Phone | (513) 585-6663 |
| Website | uchealth.com |
| Treatments | Intranasal Esketamine (Spravato), Intranasal Ketamine, TMS, ECT, Medication Management, Psychotherapy, Clinical Trials |
| Conditions Treated | Treatment-Resistant Depression, MDD, Mood Disorders, Substance Use Disorders |
| Cost | Academic medical center billing; contact for insurance details |
| Insurance | Accepts most major insurance plans through UCHealth billing |
| Clinical Lead | UC Gardner Neuroscience Institute team — 20+ physicians and staff in behavioral medicine, neuroscience, and neuroendocrinology |
HealingMaps Take: UCHealth Mood Disorders Center is the institutional heavyweight in Cincinnati’s ketamine landscape. Affiliated with the University of Cincinnati College of Medicine and designated as one of only 22 National Network of Depression Centers academic sites in the United States, this is not a boutique infusion clinic — it is a research hospital providing ketamine-based treatment within the most rigorous clinical framework available. The center offers both intranasal Spravato (the FDA-approved esketamine) and a separate intranasal ketamine protocol — having both allows clinicians to match the intervention to the patient rather than offering a one-size-fits-all approach. With 25+ ongoing clinical trials, patients here may have access to experimental protocols and next-generation treatments that no private clinic can offer. The team of 20+ physicians and staff spans behavioral medicine, neuroscience, neuroendocrinology, cognition, and addiction — a depth of expertise that means complex, multi-diagnosis patients get seen by specialists who understand the full picture. Insurance acceptance through UCHealth’s hospital billing system is broader than most private ketamine clinics. The trade-off is the academic medical center experience: appointments may take longer to schedule, the environment is clinical rather than spa-like, and the bureaucracy of a large health system can be frustrating. But for patients with complex presentations or those who want the highest level of clinical oversight, this is the gold standard in the region.
Patient Review
“Being treated at UCHealth gave me confidence that my ketamine protocol was backed by the latest research. My psychiatrist enrolled me in a clinical trial that gave me access to a treatment not available anywhere else in Ohio. The team here understands treatment-resistant depression at a level I have never encountered.”
About UCHealth Mood Disorders Center
UCHealth Mood Disorders Center is part of the UC Gardner Neuroscience Institute at the University of Cincinnati, located at 260 Stetson St, Suite 3200, Cincinnati, OH 45219. Designated as one of 22 National Network of Depression Centers academic sites in the US, the center offers intranasal esketamine (Spravato), intranasal ketamine, TMS, ECT, medication management, psychotherapy, and access to 25+ clinical trials. The center is staffed by 20+ physicians and researchers spanning behavioral medicine, neuroscience, neuroendocrinology, cognition, and addiction. UCHealth accepts most major insurance plans.
For more on how ketamine therapy works, see our complete guide to ketamine therapy.
What People Like
Academic medical center — highest level of clinical oversight. One of 22 National Network of Depression Centers in the US. 25+ clinical trials offer access to cutting-edge treatments. Both intranasal ketamine AND Spravato protocols available. Broad insurance acceptance through hospital billing. 20+ specialist physicians across neuroscience disciplines. UC College of Medicine affiliation ensures evidence-based protocols.
What People Don’t Like
No IV ketamine — intranasal only. Academic medical center environment — clinical rather than comfortable. Longer wait times for appointments than private clinics. Complex scheduling and billing bureaucracy. No KAP or psychedelic-assisted therapy model. May feel impersonal compared to boutique practices.
Getting Started at UCHealth Mood Disorders Center
Call (513) 585-6663 (513-585-MOOD) to schedule an appointment at the UCHealth Mood Disorders Center. Located at 260 Stetson St, Suite 3200, Cincinnati, OH 45219. Ask about clinical trial eligibility if you are interested in access to experimental treatments.
Learn more about the evidence behind ketamine for depression at the National Institute of Mental Health.
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