Product Description

Known For: Louisville’s holistic psychiatry practice offering both IV ketamine infusions and ketamine-assisted psychotherapy — one of the few providers in Kentucky combining traditional IV infusion with deep therapeutic integration for trauma and C-PTSD.

HealingMaps Take: Bliss Progressive Psychiatry represents a thoughtful evolution in Louisville’s ketamine landscape. Mandy Bliss, PMHNP, has positioned her practice explicitly as a psychiatric practice that offers ketamine — not a ketamine clinic that does some psychiatry. That framing matters because it means ketamine is contextualized within a comprehensive psychiatric relationship: medication management, psychotherapy, and ketamine are integrated into a single treatment plan rather than siloed as separate services. The practice offers both IV ketamine infusions (the medical-model approach) and KAP (the therapy-integrated approach), giving patients the choice — or the combination — that fits their needs. The holistic psychiatry orientation means Bliss also considers nutrition, lifestyle, and somatic factors alongside pharmacological treatment. The St. Matthews location is convenient for central Louisville. For patients with complex trauma (C-PTSD) or treatment-resistant depression who want a provider that sees the full picture rather than just administering infusions, Bliss Progressive offers the depth of a psychiatric relationship combined with the power of ketamine.

Patient Review

“Mandy Bliss changed my relationship with mental health treatment. After years of being shuffled between a psychiatrist for medications and a separate therapist, having someone who does both — and who uses ketamine strategically within that relationship — has been transformative for my C-PTSD.”

About Bliss Progressive Psychiatry

Bliss Progressive Psychiatry is a holistic psychiatric practice in St. Matthews, Louisville, KY 40207. Founded by Mandy Bliss, PMHNP, the practice offers IV ketamine infusions, ketamine-assisted psychotherapy (KAP), holistic psychiatric medication management, and psychotherapy. Bliss specializes in treatment-resistant depression, PTSD, complex PTSD (C-PTSD), anxiety, and trauma. The practice takes a progressive, integrative approach to mental health care, treating the whole patient rather than just symptoms.

For more on how ketamine therapy works, see our complete guide to ketamine therapy.

What People Like

Both IV ketamine and KAP available — flexible treatment options. Holistic psychiatry model treats the whole patient. Specializes in complex trauma (C-PTSD) — rare expertise. Single provider relationship for meds, therapy, and ketamine. Progressive, integrative philosophy. St. Matthews location is centrally accessible in Louisville.

What People Don’t Like

Specific address not publicly listed. Phone number not prominently displayed — contact primarily through website. Solo practitioner may have limited availability. Pricing not transparent on website. Insurance coverage unclear. Newer practice compared to established Louisville ketamine providers.

Getting Started at Bliss Progressive Psychiatry

Visit blisspsych.com/ketamine or blisspsych.com/contact to schedule a consultation. The practice is located in St. Matthews, Louisville, KY 40207. See blisspsych.com/pricing for treatment cost details.

Learn more about the evidence behind ketamine for depression at the National Institute of Mental Health.